Copper induces oxidative stress with triggered NFB pathway
Copper Cu is a necessary trace mineral due to its biological activity. Excessive Cu can induce inflammatory response in humans and animals, but the underlying mechanism is still unknown. Here, 240 broilers were used to study the effects of excessive Cu on oxidative stress and NFBmediated inflam Cited by: 5Copperinduced tight junction mRNA expression changes, Copperinduced tight junction mRNA expression changes, apoptosis and antioxidant responses via NFB, TOR and Nrf2 signaling molecules in the gills of fish: preventive role of arginine Affiliations 1 Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. ...Cited by: 128Antioxidant and antiinflammatory effects of zinc. Zincdependent Zinc can exchange redox active metals, such as copper and iron, in certain binding sites and attenuate cellular sitespecific oxidative injury. Studies have demonstrated that physiological reconstitution of zinc restrains immune activation, whereas zinc deficiency, in the setting of severe infection, provokes a systemic increase in NFB activation.